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Physico-Chemical characterization and evaluation of disintegrating property of Lepidium sativum seed mucilage

Archana, * and Kumar, Sandeep and Mahalaxmi, R and Shirwaikar, AA and Shirwaikar, A (2012) Physico-Chemical characterization and evaluation of disintegrating property of Lepidium sativum seed mucilage. Journal of Pharmacy Research, 5 (1). pp. 61-65. ISSN 0974-6943

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Abstract

The present work was carried out to study the physicochemical characteristics and to explore the disintegration property of the mucilage extracted from the seeds of Lepidium sativum by formulating orally disintegrating tablets of Metformin HCl by the direct compression method. Mucilage extracted from the seeds was subjected to preformulation studies for its suitability as a disintegrating agent. The mucilage extracted was evaluated for various parameters as per Indian Pharmacopoeia 1996. Several formulations with different proportions of mucilage were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution. The study revealed that Lepidium sativum seed mucilage (Ls M) is a good pharmaceutical adjuvant and is effective as a disintegrant at low concentration as 2.5%.

Item Type: Article
Uncontrolled Keywords: Lepidium sativum seed mucilage, Metformin hydrochloride, Physico chemical characterization, disintegrating property
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 07 Apr 2012 10:12
Last Modified: 07 Apr 2012 10:12
URI: http://eprints.manipal.edu/id/eprint/3723

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