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In vitro characterization of methotrexate loaded poly (lactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing

Singh, UV and Udupa, N (1997) In vitro characterization of methotrexate loaded poly (lactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing. Pharmaceutics Acta Helvetiae, 72. pp. 165-173.

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Abstract

Methotrexate (MTX) loaded poly (lactic-co-glycolic) acid (PLGA) microspheres were prepared by emulsion solvent evaporation technique. The mean diameter of the microspheres was affected by the type of emulsion stabilizer, polymer concentration, aqueous and organic phase volume and stirring speed. The in vitro release was triphasic and was dependent on copolymer composition and molecular weight of the polymer. Antitumor efficacy in Sarcoma- 180 tumor bearing mice exhibited increased volume doubling time (18 f 2.7 days) compared to plain subcutaneous injection of methotrexate (8 k 0.7 days). Preliminary pharmacokinetic studies following subcutaneous administration of MTX loaded PLGA microspheres illustrated the controlled release of the drug. The studies demonstrated the feasibility of employing PLGA as an effective carrier for antineoplastic drug like methotrexate.

Item Type: Article
Uncontrolled Keywords: Methotrexate; PLGA; In vitro release; Antitumor efficacy
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 15 Jul 2011 10:36
Last Modified: 15 Jul 2011 10:36
URI: http://eprints.manipal.edu/id/eprint/391

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