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Methotrexate loaded chitosan and chitin microspheres-in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma

Singh, UV and Udupa, N (1998) Methotrexate loaded chitosan and chitin microspheres-in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma. Microencapsulation, 15 (5). pp. 581-594.

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Abstract

Methotrexate (MTX) loaded chitosan and chitin microspheres were prepared. The physicochemical characteristics were affected by various parameters, e.g. stirring speed, concentration of chitosan and chitin. The t112 for in vitro release varied depending on the concentration of chitosan and chitin and the amount of glutaraldehyde used. The antitumour activity in Ehrlich ascites tumour bearing mice for MTX loaded chitosan microspheres was better when compared with plane MTX on oral administration. The plasma drug levels were sustained.

Item Type: Article
Uncontrolled Keywords: Chitosan, chitin, microspheres, methotrexate, in vifro release, antitumour efficacy.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 15 Jul 2011 10:36
Last Modified: 15 Jul 2011 10:37
URI: http://eprints.manipal.edu/id/eprint/393

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