Rao, R and Shenoi, Shrutakirthi D (2006) Indirect immunofluorescence to demonstrate lichen planus specific antigen (LPSA) in lichen planus. Indian J Dermatol Venereol Leprol, 72 (5). pp. 350-352.
![]() |
PDF
ijdvl725350-2162007_060020.pdf - Published Version Restricted to Registered users only Download (157kB) | Request a copy |
Abstract
Background: Current evidence suggests that lichen planus is an immunological disease. Cytotoxic CD8+ cells in the lesional epidermis recognize a unique antigen called lichen planus specific antigen. This antigen could be demonstrated by indirect immunofluorescence using the patient's serum and autologous lesional skin. Aim: To study indirect immunofluorescence pattern in lichen planus, among Indian patients. Methods: Twenty-five consecutive patients with the clinical diagnosis of lichen planus were enrolled in the study. Direct immunofluorescence was done in all patients. Indirect immunofluorescence using lesional skin as substrate was done in all 25 patients and five patients with other dermatoses. Results: A specific fluorescence pattern corresponding to the distribution of lichen planus specific antigen was observed in the stratum spinosum and granulosum in 22 (88%) patients. It was absent from other parts of the epidermis, dermis and in patients with other dermatoses.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Indirect immunofluorescence, lichen planus,lichen planus specific antigen. |
Subjects: | Medicine > KMC Manipal > Dermatology |
Depositing User: | KMC Manipal |
Date Deposited: | 01 Jul 2011 05:20 |
Last Modified: | 16 Nov 2016 11:44 |
URI: | http://eprints.manipal.edu/id/eprint/457 |
Actions (login required)
![]() |
View Item |