Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats

Shenoy, Rekha R and Sudheendra, Arun T and Nayak, Pawan G and Paula, Piya and Kutty, Gopalan N and Rao, Mallikarjuna C (2011) Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats. Journal of Ethnopharmacology, 133. pp. 608-612.

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Ethno-pharmacological relevance: The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity. Aim of the study: To investigate the influence of sesamol (SM) on wound repair, both in normal and examethasone (DM) delayed healing processes in albino rats. Materials and methods: Incision, excision and dead space wounds were inflicted on albino rats (180–220 g) of either sex, under ketamine anaesthesia. Group I served as control, group II received SM 50 mg/kg i.p., group III was treated with dexamethasone (DM) i.m. (0.17 mg/kg) and SM+DM was given to group IV. The tensile strength, wound contraction, hydroxyproline, lysyl oxidase and total RNA and DNA levels (in granulation tissue) were measured. Results: The tensile strength significantly (p < 0.05) increased withSMat 471.40±14.66 g when compared to control at 300.60±9.16 g in normal andDMsuppressed healing. No significant change was observed in duration of wound contraction and lysyl oxidase when compared to control at 2.98±0.10 mg. SM treated rats showed a significant (p < 0.05) rise in hydroxyproline levels at 6.45±0.45mg when compared to ontrol at 1.75±0.20 mg. Conclusion: These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes.

Item Type: Article
Uncontrolled Keywords: Sesamol, Dexamethasone, Lysyl oxidase, Hydroxyproline, DNA, RNA
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 13 Jul 2011 10:02
Last Modified: 23 Oct 2013 11:06

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