From Thalidomide to Rofecoxib: Can we Afford to Wait and Watch?

Khan, Sohil A and Rao, Padma GM and Rodrigues, Gabriel and Surulivelrajan, Mallayasamy and Heda, Ashish (2006) From Thalidomide to Rofecoxib: Can we Afford to Wait and Watch? International Journal of Risk & Safety in Medicine, 18. pp. 219-230.

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Abstract. Drug safety constitutes the cornerstone of modern therapeutics. Nowadays, the focus tends to be more on the hazards of drugs rather than on their benefits. This article describes from a healthcare professional’s viewpoint the history behind two major drug disasters: thalidomide and rofecoxib and the reasons why drug withdrawals continue, taking the classic example of rofecoxib despite our safety concerns and the method to overcome those disasters in the future. The paper highlights the major steps to be followed for pharmacovigilance as an effective component of drug safety. The responsibility of healthcare professionals has ultimately to do with patient care and is to promote a culture of safe and efficacious drug use and thereby preventing future disasters related to modern therapeutics.

Item Type: Article
Uncontrolled Keywords: Rofecoxib, Thalidomide, Pharmacovigilance
Subjects: Pharmacy > MCOPS Manipal > Pharmacy Practice
Medicine > KMC Manipal > Plastic Surgery
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 05 Jul 2011 09:38
Last Modified: 27 Mar 2015 07:17

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