Hepatoprotective properties of mymecylon umbellatum leaves

Shetty, Prashanth and Vijayanarayana, K and D'Souza, Ullas Prakash and Shama , Prasanna K and Shastry, CS (2011) Hepatoprotective properties of mymecylon umbellatum leaves. International Journal of Pharmaceutical Science and Biotechnology, 1 (2). pp. 313-315.

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Background and objective: Memecylon umbellatum (Family: Melastomataceae) is a shrub commonly found in Southern and East-ern Parts of India and Andaman Islands. The leaf extract of M. umbellatum has been extensively used in traditional medicine and has been found to possess hypoglycemic activity. M. umbellatum extract contains flavonoids and saponins which have antioxidant properties. The objective of this study was to evaluate the leaf extract of M. umbellatum for its protective effects against carbon tetrachloride (CC14) in-duced acute hepatotoxicity. Methods: Male Wistar albino rats (n=72) were injected tetrachloride, 0.4ml/kg, intra peritoneally daily for 7 days following which they were randomly assigned to orally receive vehicle (1% propylene glycol, 1 mg/Kg) or aqueous or alcoholic extract of M. umbellatum (100, 250 and 500 mg/kg dry weight suspended in the vehicle for 7 days. One group of rats received silymarin (125mg/kg, orally) which was used as a positive control in the experiments. A separate group of rats which were not injected carbon te-trachloride served as blank. Serum enzyme levels were assessed in blood samples obtained by direct heart puncture at the end of the treatment protocol. Results: As anticipated, serum liver enzymes SGOT, SGPT and ALP were elevated in CC14treated rats. In contrast, rats that alcoholic or aqueous extracts of M. umbellatum, and those that were treated with silymarin had significantly attenuated levels of SGOT, SGPT and ALP. There was no statistical difference between the enzyme levels in silymarin treated rats to those treated with the ex-tracts of M. umbellatum. Discussion and conclusion: Our data suggests that M. umbellatum protects against carbon-tetrachloride induced acute hepatotoxicity in rats. The hepato protective effect of M. umbellatum was comparable to the standard drug silymarin. Since, carbon tetrachloride induces hepatotoxicity via free radical formation; it is tempting to speculate that Memecylon umbelatum may be mediating its hepatoprotective properties by inhibiting free radicals.

Item Type: Article
Uncontrolled Keywords: Memecylon umbellatum, hepatoprotective, carbon tetra chloride, flavonoids
Subjects: Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 13 Jul 2011 04:11
Last Modified: 13 Jul 2011 04:11
URI: http://eprints.manipal.edu/id/eprint/535

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