Anti-urolithiatic activity of heart wood extract of cedrus deodara in rats

Ramesh, C and Krishnadas, Nandakumar and Radhakrishnan, Rajesh and Rangappa, Srinath and Viswanatha, Gollapalle Lakshminarayana Shastry and Rajesh, D and Gopal, Murugananthan and Talwar, Sahil (2010) Anti-urolithiatic activity of heart wood extract of cedrus deodara in rats. Journal of Complementary and Integrative Medicine, 7 (1). pp. 1-9.

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Abstract

The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.

Item Type: Article
Uncontrolled Keywords: Anti-urolithiatic, Diuretic, Cedrus deodara
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 12 Jul 2011 10:51
Last Modified: 07 Nov 2016 10:43
URI: http://eprints.manipal.edu/id/eprint/547

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