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Evaluation of antiplaque activity of Azadirachta indica leaf extract gel — A 6 week clinical study.

Pai, Raveendra M and Acharya, Leelavathi D and Udupa, N (2004) Evaluation of antiplaque activity of Azadirachta indica leaf extract gel — A 6 week clinical study. Journal of Ethnopharmacology, 90. pp. 99-103.

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Abstract

Various chemical agents have been evaluated over the years with respect to their antimicrobial effects in the oral cavity; however, all are associated with side effects that prohibit regular long-term use. Therefore, the effectiveness of neem (Azadirachta indica A. Juss) leaf extract against plaque formation was assessed in males between the age group of 20–30 years over a period of 6 weeks. Present study includes formulation of mucoadhesive dental gel containing Azadirachta indica leaf extract (25 mg/g). A 6-week clinical study was conducted to evaluate the efficacy of neem extract dental gel with commercially available chlorhexidine gluconate (0.2% w/v) mouthwash as positive control. Microbial evaluation of Streptococcus mutans and Lactobacilli species was carried out to determine the total decrease in the salivary bacterial count over a period of treatment using a semi-quantitative four quadrant streaking method. The results of the study suggested that the dental gel containing neem extract has significantly (P < 0.05) reduced the plaque index and bacterial count than that of the control group.

Item Type: Article
Uncontrolled Keywords: Gels, Neem, Azadirachta indica,Chlorhexidine,Plaque index,Salivary microbial count
Subjects: Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 12 Jul 2011 10:29
Last Modified: 08 Oct 2013 04:25
URI: http://eprints.manipal.edu/id/eprint/552

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