Highly Active Antiretroviral Therapy Induced Cutaneous Adverse Drug Reactions in Patients with Human Immunodeficiency Virus Infection

Radhakrishnan, Rajesh and Vidyasagar, Sudha and Johnson, Subin and Singh, Sonika and Sharma, Shreekant (2010) Highly Active Antiretroviral Therapy Induced Cutaneous Adverse Drug Reactions in Patients with Human Immunodeficiency Virus Infection. Pharmacologyonline, 3. pp. 101-118.

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Abstract

Worldwide, over 40 million people are infected with the Human Immunodeficiency Virus (HIV). The High Activity Antiretroviral Therapy (HAART) combines at least three antiretroviral (ARV) drugs and, for over a decade, has been used to extend the lifespan of the HIV-infected patients. HIV-infected patients have a higher risk of developing cutaneous reactions than the general population, which has a significant impact on patients’ current and future care options.The severity of dermatologic and cutaneous adverse reactions varies greatly, and some may be difficult to manage. HIV-infected patients just at the beginning of High Activity Antiretroviral Therapy can frequently show a wide variety of adverse drug effects such as erythema multiforme, urticarial reaction, hyperpigmentation, drug rashes, toxic epidermal necrolysis or Stevens–Johnson syndrome. The early detection and treatment of cutaneous adverse drug reactions, identification of the causative agent, are essential to prevent the progression of the reaction. This review gives an overview of the most common features of a highly active antiretroviral therapy induced dermatological and cutaneous adverse reactions from Nucleoside Reverse Transcriptase Inhibitors (NtRTIs), Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs), Protease Inhibitors (PIs), Entry Inhibitors, Integrase Inhibitors, Maturation inhibitors. Paying special attention to the newest drugs approved for the treatment of HIV infection, such as rilpivarine, maraviroc, vicriviroc, raltegravir, elvitegravir and bevirimat.

Item Type: Article
Uncontrolled Keywords: Highly active antiretroviral therapy,cutaneous adverse drug reactions, human immunodeficiency virus.
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 06 Jul 2011 06:14
Last Modified: 01 Oct 2013 05:20
URI: http://eprints.manipal.edu/id/eprint/556

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