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A study of rivastigmine liposomes for delivery into the brain through intranasal route.

Armugam, Karthik and Subramanian, Ganesa Sundararajan and Surulivelrajan, Mallayasamy and Averineni, Ranjith Kumar and Reddy, Meka Sreenivasa and Udupa, Nayanabhirama (2008) A study of rivastigmine liposomes for delivery into the brain through intranasal route. Acta Pharm, 58. pp. 287-297.

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Abstract

The present study is mainly aimed at delivering a drug into the brain via the intranasal route using a liposomal formulation. For this purpose, rivastigmine, which is used in the management of Alzheimer’s disease, was selected as a model drug. Conventional liposomes were formulated by the lipid layer hydration method using cholesterol and soya lecithin as lipid components. The concentration of rivastigmine in brain and plasma after intranasal liposomes, free drug and per oral administration was studied in rat models. A significantly higher level of drug was found in the brain with intranasal liposomes of rivastigmine compared to the intranasal free drug and the oral route. Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug. Delivering rivastigmine liposomes through the intranasal route for the treatment of Alzheimer’s disease might be a new approach to the management of this condition

Item Type: Article
Uncontrolled Keywords: rivastigmine, liposomes, intranasal administration, brain drug delivery, pharmacokinetics
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Manipal
Date Deposited: 09 Jul 2011 04:35
Last Modified: 08 Oct 2013 10:42
URI: http://eprints.manipal.edu/id/eprint/628

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