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Gender differences in the pharmacokinetics of rivastigmine in rats

Arumugam, Karthik and Chamallamudi, Mallikarjuna Rao and Surulivelrajan, Mallayasamy and Subramanian, Ganesan and Shavi, Gopal V and Averineni, Ranjith Kumar and Reddy, Ravindranath and Bhat, Krishnamurthy and Udupa, Nayanabhirama (2009) Gender differences in the pharmacokinetics of rivastigmine in rats. Arzneimittelforschung, 59 (10). pp. 493-497.

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Abstract

The effect of gender on the pharmacokinetics of rivastigmine (CAS 123441-03-2) was studied in male and female Wistar rats following intravenous bolus administration. The area under the plasma concentration-time curve (AUC), apparent volume of distribution (Vd), systemic clearance (CL), and terminal plasma halflife (t1/2) of rivastigmine were compared between male and female rats. Compared to male rats, female rats exhibited higher plasma rivastigmine levels showing significantly (p < 0.05) larger AUC (226.77 vs. 149.68 ng h/ml), Vd (6.70 vs. 4.13 L), t1/2 (0.84 vs. 0.34 h) and a lower CL (5.51 vs. 8.35 L/h). The male rats had a 2.5 fold greater elimination rate constant than female rats (2.02 vs. 0.82 h(-1)). Gender had a significant effect on the pharmacokinetics of rivastigmine. Gender differences were reported due to gonadal hormones, and the observed difference in pharmacokinetics of rivastigmine might be attributed to testosterone in male rats.

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2011 05:25
Last Modified: 02 Nov 2016 09:27
URI: http://eprints.manipal.edu/id/eprint/645

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