The role of pharmacist in development of pharmacogenetic testing and important updates of pharmacogenomics

Raj, Vasanth P and Thiyagu, R and Chandrasekar, Raghu H and Surulivelrajan, Mallayasamy and Rao, Venkata J and Rao, Mallikarjuna C (2009) The role of pharmacist in development of pharmacogenetic testing and important updates of pharmacogenomics. Pharmacologyonline, 1. pp. 90-102.

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The field of ‘pharmacogenetics’, which is ‘the study of variability in drug response due to heredity’, should help in reducing drug-caused morbidity and mortality. The recently coined term ‘pharmacogenomics’ usually refers to ‘the field of new drug development based on our rapidly increasing knowledge of all genes in the human genome’. However, the two terms – pharmacogenetics and pharmacogenomics – are often used interchangeably. The pharmacist, as well as the medical genetics counselor, should be knowledgeable in the rapidly expanding fields of pharmacogenetics and pharmacogenomics. The history of Pharmacogenetics, Drug polymorphisms, phenotypegenotype and its Correlation, Single Nucleotide polymorphism (SNP) and the role of Pharmacist in development of pharmacogenetic testing are discussed in detail. Our current appreciation of the degree of variability (including single-nucleotide polymorphisms, SNPs) in the human genome is described; ethical considerations and the possibility of a total genome scan at high resolution termed as Quantitative trait loci (QTL) mapping are also highlighted in this article. Finally, Drug metabolizing enzymes (DMEs) and individual’s risk of cancer are also discussed in detail. Thus the need for pharmacist to keep themselves abreast of the latest information in the fields of Pharmacogenetics and pharmacogenomics is emphasized

Item Type: Article
Uncontrolled Keywords: Pharmacogenomics, Pharmacogenetics, Single Nucleotide Polymorphism, Pharmacist.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2011 05:01
Last Modified: 26 Dec 2013 06:35

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