Effect of berberis aristata on type i and ii diabetes mellitus Models in albino rats

Rameshwar, Naresh Kumar and Shenoy, Rekha Raghuveer and Theerthahalli, Arun Sudheendra and Rao, Mallikarjuna C (2009) Effect of berberis aristata on type i and ii diabetes mellitus Models in albino rats. Pharmacologyonline, 1. pp. 89-96.

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Abstract

Aim: To explore the anti-diabetic potential of Berberis aristata in rodents Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocininduced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model.

Item Type: Article
Uncontrolled Keywords: Streptozotocin, Oxidative stress, Wistar strain, Nicotinamide
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2011 04:48
Last Modified: 23 Oct 2013 11:11
URI: http://eprints.manipal.edu/id/eprint/653

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