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Identification and evaluation of antioxidant analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized

Prabhakar, KR and Veerapur, VP and Bansal, Punit and Vipan, Parihar K and Reddy, KM and Barik, Atanu and Reddy, Bharat Kumar D and Reddanna, P and Priyadarsini, KI and Unnikrishnan, MK (2006) Identification and evaluation of antioxidant analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized. Bioorganic & Medicinal Chemistry, 14. pp. 7113-7120.

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Abstract

Treatment of phenols with ninhydrin in acidic medium afforded 2-hydroxy-2-(ortho-hydroxy-phenyl/naphthyl)-1,3-dioxoindanes,which being unstable were isolated in their hemiketal forms. These synthesized compounds were subjected to TLC screening for radical scavenging and in vitro lipoxgenase and cycloxygenase enzyme inhibition assays. The best compound was identified and studied in detail for steady-state and time-resolved free radical kinetics, viz., DPPH, ABTS��, �OH and rate constants for these reactions were evaluated. The best compound was also subjected to in vivo anti-inflammatory and analgesic activities in which the compound showed good promise for further structural optimization

Item Type: Article
Uncontrolled Keywords: Ninhydrin–phenol adducts, Free radicals, Antioxidant, Anti-inflammatory, Analgesic
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2011 04:28
Last Modified: 13 Jul 2011 11:21
URI: http://eprints.manipal.edu/id/eprint/657

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