Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats

Veerapur, VP and Prabhakar, KR and Parihar, Vipan Kumar and Bansal, Punit and Srinivasan, KK and Priyadarsini, KI and Unnikrishnan, MK (2010) Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats. International Journal of Phytomedicine, 2. pp. 59-70. ISSN 0975-0185

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Abstract

We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16% and 72.9% respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and libenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non- nzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.

Item Type: Article
Uncontrolled Keywords: Antidiabetic, Antioxidant enzymes, Dodonaea viscosa, Free radical scavenger, Hypolipidaemic, Streptozotocin
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2011 03:48
Last Modified: 11 Jul 2011 03:48
URI: http://eprints.manipal.edu/id/eprint/659

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