Oral manifestations as predictors of immune suppression in a HIV-/AIDS-infected population in South India

Sharma, Gaurav and Pai, Keerthilatha M and Setty, Suhas and Ramapuram, John T and Nagpal, Archna (2009) Oral manifestations as predictors of immune suppression in a HIV-/AIDS-infected population in South India. Clin Oral Invest, 13 (2). pp. 141-148.

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The objectives of the study are to evaluate the relationship between common HIV-related oral lesions and absolute CD4+ count, age, gender, and medication used and to assess the sensitivity, specificity, positive and negative predictive value of oral manifestations for low absolute CD4+ counts. HIV-positive patients, 200, from south India were selected, whose absolute CD4+ counts were determined within 2 weeks of oral examination. Sociodemographic data was obtained using a structured questionnaire. Oral manifestations were diagnosed according to presumptive criteria of EEC-clearinghouse classification (1993). Four or more concurrent oral lesions were statistically significant with low CD4+ counts <200 cells/mm3 (P= 0.005). The highest and lowest mean CD4+ cell counts were seen in individuals with linear gingival erythema (LGE; 172.5 cells/mm3) and pseudomembranous candidiasis (PC; 87 cells/mm3), respectively. Smoking, age (<35 years), and males had a positive association with oral hairy leukoplakia (OHL; P<0.05). Patients with CD4+ counts<200 cells/mm3 were associated with 15 times greater risk of PC and four times at greater risk for occurrence of any oral manifestation. Concurrent oral manifestations (≥4) were good predictors (80–100%) of severe immune suppression. In most resource poor countries where facilities for undertaking CD4+ counts are not available, the presence of concurrent oral manifestations may be used as an indicator of deteriorating immune status.

Item Type: Article
Uncontrolled Keywords: HIV, AIDS,Oral manifestations,India,CD4 count
Subjects: Dentistry > MCODS Manipal > Oral Medicine and Radiology
Medicine > KMC Manipal > Medicine
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2011 06:32
Last Modified: 11 Jul 2011 06:32
URI: http://eprints.manipal.edu/id/eprint/666

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