Action of Portulaca oleracea against Streptozotocin-Induced Oxidative Stress in Experimental Diabetic Rats

Sharma, Alok and Vijayakumar, M and Rao, ChV and Unnikrishnan, MK and Reddy, GD (2009) Action of Portulaca oleracea against Streptozotocin-Induced Oxidative Stress in Experimental Diabetic Rats. Journal of Complementary and Integrative Medicine, 6 (1). pp. 1-10.

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Abstract

Antidiabetic treatment with an extract of Portulaca oleracea leaves (100mg/kg and 250mg/kg body weight) for three weeks showed a significant reduction in thiobarbituric acid reactive substances (TBRAS) and an increase in glutathione reductase (GSH-R) in both the liver and kidney of STZ diabetic rats. The treatment with P. oleracea significantly altered the glutathione and GSHR to be comparable with the control group. P. oleracea- and tolbutamide-treated rats showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase(CAT). The effects of P. oleracea on tissue lipid peroxidation and antioxidant status in diabetic animals have not been studied before. The result of this study thus shows that although P. oleracea extract possesses moderate antidiabetic activity, it exhibits potent antioxidant potential in diabetic conditions.

Item Type: Article
Uncontrolled Keywords: Portulaca oleracea, Portulacaceae, antioxidant enzymes, diabetes
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 18 Jul 2011 05:00
Last Modified: 18 Jul 2011 05:00
URI: http://eprints.manipal.edu/id/eprint/681

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