Akkati, Sindhu and Sam, Kishore Gnana and Thunga, Girish (2011) Emergence of Promising Therapies in Diabetes Mellitus. Journal of Clinical Pharmacology , 51. pp. 796-804.

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Abstract

Diabetes mellitus (DM) results from defects in insulin secretion (type 1) or insulin resistance (type 2). Insulin is used to manage type 1 DM, and oral hypoglycemic agents are used to manage type 2 DM. These therapies are inconsistent in maintaining glycemic control and cause some severe adverse effects such as undue weight gain and hypoglycemia. New and appropriate therapies are needed to overcome these problems. Drugs that are in the pipeline include oral insulins for type 1 DM and incretin mimetics, incretin enhancers, gastric inhibitory peptides, amylin analogues, peroxisome proliferator-activated receptor-α/γ ligands, sodium-dependent glucose transporter inhibitors, and fructose 1,6-bisphosphatase inhibitors for type 2 DM. This article describes the mechanisms of action and relative advantages and disadvantages of the promising therapies

Item Type:	Article
Uncontrolled Keywords:	Oral insulin, incretin mimetics, incretin enhancers, gastric inhibitory peptides, amylin analogues, peroxisome proliferator-activated receptor-α/γ ligands, sodium dependent glucose transporter inhibitors, fructose 1, 6-bisphosphatase inhibitors
Subjects:	Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User:	KMC Manipal
Date Deposited:	18 Jul 2011 05:00
Last Modified:	18 Oct 2013 10:27
URI:	http://eprints.manipal.edu/id/eprint/688

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