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Ventilator-Associated Pneumonia with Col-S Strains: A Successful Comeback of Colistin!

Mukhopadhyay, C and Krishna, S and Shenoy, A and Vandana, KE and Bairy, I (2008) Ventilator-Associated Pneumonia with Col-S Strains: A Successful Comeback of Colistin! The Brazilian Journal of Infectious Diseases, 12 (5). pp. 444-446.

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Abstract

Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multidrug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broadspectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug resistant strains as early as possible; colistin, the ‘last resort’ antibiotic, if instituted with proper monitoring at the right time, can be life saving.

Item Type: Article
Uncontrolled Keywords: Colistin, Col-S strain, ventilator-associated pneumonia
Subjects: Medicine > KMC Manipal > Anaesthesiology
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Manipal
Date Deposited: 28 May 2011 04:23
Last Modified: 28 May 2011 04:23
URI: http://eprints.manipal.edu/id/eprint/74

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