Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma

Rayabandla, Sunil Kumar Mandala and Aithal, Kiran and Anandam, Aravind and Shavi, Gopal and Udupa, Nayanabhirama and Arumugam, Karthik and Musmade, Prashant B and Bhat, Krishnamoorthy and Rao, Satish BS (2010) Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma. Drug Delivery, 17 (3). pp. 1-11. ISSN 1071-7544

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Abstract

The present study was aimed to evaluate the anti-tumor efficacy and systemic toxicity of chitosan-based plumbagin microspheres in comparison to free plumbagin. The optimized formulation had a mean particle size of 106.35 μm with an encapsulation efficiency of 80.12%. Pharmacokinetic studies showed a 22.2-fold increase in elimination half-life (t1/2) of plumbagin from chitosan microspheres as compared to free plumbagin. Administration of plumbagin microspheres resulted in a significant tumor growth inhibition and reduced systemic toxicity. These results suggest that chitosan-based microspheres could be a promising strategy for the systemic delivery of anti-cancer agents like plumbagin.

Item Type: Article
Uncontrolled Keywords: Plumbagin; chitosan; microspheres; pharmacokinetics; pharmacodynamics
Subjects: Life Sciences > MLSC Manipal
Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 21 Apr 2012 07:06
Last Modified: 05 Nov 2016 09:54
URI: http://eprints.manipal.edu/id/eprint/76287

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