Rao, Lavanya G and Addoor, Krishna Rao and Bhandary, Sulatha V and Jain, Vikram (2011) Homocysteine Levels in Patients with Retinal Venous Occlusions. Kerala Journal of Opthalmology, 23 (1). pp. 56-58.

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Abstract

Aim: 1. To evaluate homocysteine levels in patients with retinal venous occlusions 2. To determine possible association between visual outcome and homocysteine levels in patients with retinal venous occlusions. Design: Case Control Study. Methods: 20 patients with recent retinal venous occlusions over the last one year underwent serum homocysteine level analysis. Age and sex matched, two control groups (group I patients with diabetes mellitus without retinal venous occlusive disease and group II non diabetics without retinal venous occlusive disease) were selected. Results: 16 of 20 patients (80%) with retinal venous occlusion had elevated fasting serum homocysteine levels, whereas only 10 out of 20 controls (50%) had an abnormal homocysteine level. Average homocysteine levels in patients with retinal venous occlusion (20.86 μmol/L) was higher than in controls (16.33 μmol/L). Average age of patients with retinal venous occlusion and increased homocysteine (55.37 years) was lower by 5 years than that of patients with retinal venous occlusion and normal homocysteine levels (60.33 years). In patients with CRVO, visual acuity was better in patients with normal homocysteine when compared to those with elevated homocysteine. Conclusion: Patients with retinal venous occlusive disease had higher levels of homocysteine, which may serve as a modifiable risk factor.

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