Clinical profile of brucellosis from a tertiary care center in southern India

Sathyanarayanan, Vishwanath and Razak, Abdul and Saravu, Kavitha and Shastry, Ananthakrishna Barkur and Prabhu, Mukhyaprana and Vandana, KE (2011) Clinical profile of brucellosis from a tertiary care center in southern India. Asian Pacific Journal of Tropical Medicine, 4 (5). pp. 397-400.

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Abstract

Objective: To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis.Methods : Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation.Results: Of the 68 patients, 46 (68%) were male and 22 (32%) were female patients with age distribution of 9-75 years. Forty four (64.7%) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100%), myalgia (21, 31%), musculoskeletal symptoms (23, 34%), headache (16, 24%), gastrointestinal symptoms (19, 28%) and altered sensorium (3, 4%). Co-morbidities and associations included HIV positivity (2, 3%), type 2 diabetes mellitus (13, 19%), steroid therapy (3, 4%) and HBsAg positivity (8, 12%). Ten (15%) patients had cervical lymphadenopathy, 4(6%) had splenic enlargement, 6 (7%) had hepatomegaly, 19 (28%) had hepatosplenomegaly and 2(3%) got meningeal signs. Anaemia was observed in 39 (57.3%) cases, high erythrocyte sedimentation rate (ESR) was present in 55 (80.8%) cases, leucocytosis in 10(14.7%), leucopenia in 10(14.7%), thrombocytopenia in 23 (33.82%) and thrombocytosis in 2 (2.94%) cases. Conclusions : In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.

Item Type: Article
Uncontrolled Keywords: Brucella ; South India ; BACTEC ; Standing agglutination test
Subjects: Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Manipal
Date Deposited: 27 Apr 2012 06:47
Last Modified: 09 Oct 2013 06:24
URI: http://eprints.manipal.edu/id/eprint/76343

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