Multiparticulate Drug Delivery System of Aceclofenac: Development and In Vitro Studies

Shavi, Gopal Venktesh and Nayak, Usha and Averineni, Ranjith Kumar and Arumugam, Karthik and Reddy, Srinivasa Meka and Udupa, Nayanabhirama and Pandey, Sureshwar (2009) Multiparticulate Drug Delivery System of Aceclofenac: Development and In Vitro Studies. Drug Development and Industrial Pharmacy, 35 (2). pp. 252-258. ISSN 0363-9045

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The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal antiinflammatory drug. The pellets were prepared by using extrusion/ spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specific drug release. The formulated pellets were characterized for percentage yield, size distribution, surface morphology studies, drug content, and flow properties. In vitro dissolution test was used for comparison of drug release profiles of various coated pellets. The practical yield was found to be 90– 95%. The particle size of enteric-coated pellets was found to be in the range of 0.59–0.71 mm. The pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated pellets showed good flow properties and in vitro dissolution profile. Dissolution tests were carried out in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formulated pellets was established to be minimum in the pH 1.2 (<5%) for a period of 2 h, and at pH 6.8, it shows the maximum release (85 ± 5% release within 1 h) which indicates gastric resistance of the formulated pellets. The 20% wt/wt enteric-coated pellets were compared to that of marketed product (tablets), it was observed that pellets showed better release profile. The study concluded that the formulated multiparticulate dosage forms can be used as an ideal drug delivery system for the aceclofenac.

Item Type: Article
Uncontrolled Keywords: enteric-coated pellets; aceclofenac; eudragit L100-55; NSAID; multiparticles
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 28 Apr 2012 04:15
Last Modified: 28 Apr 2012 04:15

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