Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine

Nayak, Usha Yogendra and Shavi, Gopal V and Averineni, Ranjith Kumar and Reddy, Sreenivasa Meka and Gupta, Purushotham and Udupa, Nayanabhirama (2009) Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine. Journal of Microencapsulation,, 26 (3). pp. 214-222. ISSN 0265-2048

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Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2% acetic acid solution and this solution was dispersed in the light liquid paraffin. Span- 80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60–210 mm, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60% of entrapment and release was extended up to 18–24 h. Among all the systems studied, the 35% Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75% release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drug–polymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.

Item Type: Article
Uncontrolled Keywords: Zidovudine; microspheres; chitosan; glutaraldehyde; kinetic models
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 28 Apr 2012 04:19
Last Modified: 28 Apr 2012 04:19

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