Effect of furosemide (loopdiuretic) on ingestive behavior. body weight and certain haematological parameters in Adult Wistar Rats

Mantur, Venkappa S. and *, N. A. Vinodini and *, A. K. Nayanatara and *, A. V. Ranade and *, C. Ramaswamy and Chatterjee, Pratik K. and *, K. Kishan (2012) Effect of furosemide (loopdiuretic) on ingestive behavior. body weight and certain haematological parameters in Adult Wistar Rats. International Journal of Pharmaceutical Sciences and Research, 3 (3). pp. 811-814. ISSN 0975-8232

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Abstract

The present experiment was aimed to examine the effect of furosemide (loop diuretic) on ingestive behavior & some hematological parameters. The adult Wistar rats (n=6/ group) were divided into control group (n =6; Group I) and experimental group (n =6; Group II). The experimental group received furosemide intraperitonially (40mg/kg BW) for a duration of 30 days. The control group of rats was injected with distilled water of same volume intraperitonially. Body weight, food and water intake was measured each day. At the end of the experimental procedure; blood samples were collected to measure the hematological parameters such as total leukocyte count (TLC), blood cell (RBC) count , Packed cell volume (PCV) and hemoglobin (Hb) concentration. The results were analyzed statistically by using student‘t test. P < 0.05 was considered as significant. Our present results showed that, administration of furosemide showed a significant increase (P < 0.001) in the ingestive behavior and body weight. Further, the RBC count, PCV, Hb concentration also showed a significant increase (P < 0.05) whereas the TLC showed a significant decrease (P < 0.05). The present data suggests that furosemide intake alters the ingestive behavior, body weight and causes the variations in observed hematological parameters.

Item Type: Article
Uncontrolled Keywords: Furosemide, RBC, WBC, TLC, ingestive behavior
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 02 May 2012 11:23
Last Modified: 02 May 2012 11:23
URI: http://eprints.manipal.edu/id/eprint/76360

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