Effect of Clobetasol Propionate and Clobetasol Butyrate with Biopolymer on Skin Inflammatory Model in Wistar Rats

Bairy, KL and Pawan Kumar, AV and Chandrashekar, BR and Holla, Avinash M and Christopher, Rockson and Sirigiri, Purnima and Satish Kumar, MC (2012) Effect of Clobetasol Propionate and Clobetasol Butyrate with Biopolymer on Skin Inflammatory Model in Wistar Rats. Journal of Applied Pharmaceutical Science , 2 (2). pp. 66-68.

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Abstract

The treatment of chronic inflammatory skin conditions are not satisfactory. There is a need for better antiflammatory drugs for these conditions. This study was done to compare the efficacy of biopolymer based formulations of clobetasol propionate and clobetasol butyrate with commercially available Preparations of clobetasol in animal models of superficial skin inflammation in rats. The croton oil ear edema in rats was the chronic inflammatory model used in this study. In this model, the animals treated with clobetasol propionate and clobetasol butyrate with biopolymer showed a significant decrease in inflammation as compared to commercially available preparations of clobetasol(Tenovate and Eumosone).

Item Type: Article
Uncontrolled Keywords: Atopic dermatitis, biopolymer, clobetasol propionate, clobetasol.
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 15 May 2012 04:53
Last Modified: 15 May 2012 04:53
URI: http://eprints.manipal.edu/id/eprint/76409

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