Evalution of adjuvant chemotherapy and efficacy of commonly used regimens in colorectal cancer

Meena Kumari, K and Bairy, KL and Amberkar, Mohan Babu V and Vadhiraja, BM and Vidyasagar, MS (2012) Evalution of adjuvant chemotherapy and efficacy of commonly used regimens in colorectal cancer. Al Ameen J Med Sci, 5 (2). pp. 116-123.

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Abstract

Objective: to know the evolution of adjuvant chemotherapy treatment given and to evaluate the efficacy of two commonly used regimens. Background: Colorectal cancer in Indian population is on upward swing due to the change in dietary habits and many other factors. The treatment of colorectal cancer has changed drastically over a period of time. Method: Patients diagnosed of this cancer and treated with adjuvant chemotherapy from 1997 to 2006 in our hospital were included for the study. Patients treated from 1997-2001 were followed up for a period of five years. The efficacy of two regimens were analyzed by five year overall survival rates in the respective group. Results: 5 fluorouracil monotherapy and 5-fluorouracil with levamisole were the commonly used regimens during 1997 - 2001 whereas in the later half, 5-fluorouracil+ leucovorin was the commonest regimen. Five year overall survival was 46% & 20% in stage B & C in 5- fluorouracil + levamisole group whereas it was 36% and 10 % respectively in 5- fluorouracil monotherapy group. Conclusion: We conclude from our findings that 5- fluorouracil+ levamisole regimen had better five year overall survival than 5-fluorouracil.

Item Type: Article
Uncontrolled Keywords: Adjuvant chemotherapy, Overall survival, 5-fluorouracil, 5-fluorouracil+ levamisole
Subjects: Medicine > KMC Manipal > Pharmacology
Medicine > KMC Manipal > Radiotherapy and Oncology
Depositing User: KMC Manipal
Date Deposited: 15 May 2012 05:11
Last Modified: 27 Oct 2016 09:21
URI: http://eprints.manipal.edu/id/eprint/76416

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