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Protein carbonyl content and thiols in patients with rheumatoid arthritis

*, Sreekantha and *, R.Kowsalya and *, S.S.Avinash and *, Vinod Chandran and *, Remya and *, M. Amareshwara (2011) Protein carbonyl content and thiols in patients with rheumatoid arthritis. Biomedicine, 31 (4). pp. 555-557.

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Abstract

Abstract Objectives: Proteins modified under oxidative stress seem to playa pivotal role in pathogenesis of several diseases. The present study was undertaken to know the relation between protein carbonylation and antioxidants in the form of glutathione and albumin in rheumatoid arthritis patients. Methods: Protein carbonylation & glutathione levels were measured in plasma in all the 30 patients and 25 controls using spectrophotometric methods along with total protein and albumin. Results•: There was significant increase in protein carbonylation content (P<O.OOl) associated with a significant decrease in glutathione and albumin levels (P<O.OOl) in patients compared to healthy controls. A significant negative correlation of protein carbonylation with glutathione and albumin was also noted. Conclusion: Thus our study suggests a possible role for oxidatively modified proteins in form of protein carbonyls in mediation of inflammation in rheumatoid arthritis leading to increased consumption of available antioxidants in the body.

Item Type: Article
Uncontrolled Keywords: Albumin, glutathione, protein carbonylation,rheumatoid arthritis
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 17 May 2012 10:49
Last Modified: 17 May 2012 10:49
URI: http://eprints.manipal.edu/id/eprint/76432

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