Drug Utilization Pattern in Urinary tract infections: A Retrospective study.

Chowta, Dr. Mukta N (2011) Drug Utilization Pattern in Urinary tract infections: A Retrospective study. Journal of Medical Science & Clinical Ressearch, 1. pp. 13-19.

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Introduction: Urinary tract infections (UTI) are a frequent problem in primary care. The empirical treatment of UTI requires constant updating of the antibiotic sensitivity of the main uropathogens of the area, country or institution. Methods: The study was designed as a descriptive, retrospective study including both male & female patients of all age groups. The case record files were retrieved from the medical records department based on the ICD-10 disease coding. The demographics were recorded. Total admissions, first admission and readmissions were identified and medication status of all patients at admission and at discharge was ascertained. Drug utilization pattern was compared among different age groups (1-10 years, 10-20years, 21-40 years, 41-60 years, >60 years) of patients. Results: A total of 88 patients were included in the study, out of which 47 (53.4%) were males and 41 (46.6%) were females. Most of the patients were in above 60 years age group. Cephalosporins were the most commonly used antibiotic (72.7%) followed by penicillins (9.1%), fluroquinolones (6.8%) and aminoglycosides (6.8%). Among the patients who received cephalosporins, third generation parenteral cephalosporins (cefotaxime, ceftriaxone, cefaperazone, ceftazidime) were used initially which was switched over to third generation oral cephalosporins (cefixime) in 24 patients after 4 days. Among the penicillins, piperacillin+tazobactum combination was used in 7 patients and amoxicillin was used in 1 patient. Amikacin was the most commonly used aminoglycosides followed by gentamicin and netilmicin. Mean duration of treatment is 5.9±2.52 days with a minimum duration of two days and maximum of 13 days. Conclusion: The present study concludes that third generation cephalosporin as first line drugs irrespective of the causative agent for UTI. Third generation cephalosporins should be reserved for complicated UTIs. These results highlight the necessity for a remedial education program within the health care system designed to improve adherence to the guidelines for the treatment of UTI.

Item Type: Article
Uncontrolled Keywords: Cephalosporins, Aminoglycosides, Penicillins, Urinary Tract Infection
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 25 May 2012 07:03
Last Modified: 25 May 2012 07:03
URI: http://eprints.manipal.edu/id/eprint/76510

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