Hypolipidemic Activity of Phyllanthus Emblica Linn (Amla) & Trigonella Foenum Graecum (Fenugreek) Combination In Hypercholesterolemic Subjects – A Prospective, Randomised, Parallel, Open-Label, Positive Controlled Study

Joseph, Santhosh and *, Divya Santhosh and Udupa, A. L. and Gupta, Subir and *, Nkemcho Ojeh and *, U.P.Rathnakar and Benegal, Deepa and Benegal, Adarsha and *, Vijayalakshmi and *, H.V. Shubha and *, Sahana P Rao and *, Sanjana P Rao and Mudium, Raghunandan (2012) Hypolipidemic Activity of Phyllanthus Emblica Linn (Amla) & Trigonella Foenum Graecum (Fenugreek) Combination In Hypercholesterolemic Subjects – A Prospective, Randomised, Parallel, Open-Label, Positive Controlled Study. Asian Journal of Biochemical and Pharmaceutical Research, 2 (1). pp. 225-230.

[img]
Preview
PDF
P.Emblica_Santhosh_Mar20_12_not_sent.pdf - Published Version

Download (155kB)

Abstract

The present study is aimed at to evaluate the hypolipidemic and antioxidant activity of combination of fenugreek and amla in hyperlipidemic subjects.Twenty eight subjects were selected from outpatient department of medicine with the inclusion criteria of total cholesterol > 220mg/dl and or serum triglyceride >140mg/dl. They were enrolled for a period of 12 weeks after obtaining written informed consent. Subjects were randomly divided into 2 groups. Group I [test drug combination -1000mg Amla + 500mg Fenugreek/day] and Group II [standard drug Atorvastatin 10 mg daily]. Subjects were evaluated every 4 weeks for 12 weeks. During these visits biochemical investigations of lipid profile and antioxidant activity were done. At the end of 12 weeks, there were significant decrease in serum total cholesterol (20-26%), LDL (25-34%), triglyceride (15- 30%) and VLDL (15-30%) levels & an increase in the HDL (0-5%) in the test drug group. This combination has shown similar response on lipid profile as statins with lesser adverse effects. Antioxidant activity of the combination is also demonstrated in the trial.

Item Type: Article
Uncontrolled Keywords: Hypolipidemic, Phyllanthus emblica Linn, Trigonella foenum graecum antioxidant, Fenugreek, Amla.
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 25 May 2012 07:23
Last Modified: 25 May 2012 07:23
URI: http://eprints.manipal.edu/id/eprint/76514

Actions (login required)

View Item View Item