Validation of Glucose Tolerance Test in the Diagnosis and Management of Gestational Carbohydrate Intolerance

Kushtagi, Pralhad (2000) Validation of Glucose Tolerance Test in the Diagnosis and Management of Gestational Carbohydrate Intolerance. Asian J Obs & Gynae Practice , 4 (1). 35-36 & 55.

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Abstract

Objective: To validate efficacy of glucose tolerance test (GTT) in the diagnosis and treatment of gestational carbohydrate intolerance. Design: The prospective clinic-biochemical study involved 120 gravide. Based on postprandial sugar profile (PPS), 90 gravidae with abnormal GTT were divided into two groups: those with a) normal PPS getting no treatment (n=30); b) abnormal PPS on treatment and those receiving treatment based only on abnormal GTT (n=60). Setting: A teaching tertiary care hospital. Results: among the study groups, 20% women with abnormal GTT on treatment were found to have suboptimal glycaemic control. Higher incidence of neonatal hypoglycaemia (15 of 60 vs. 2 of 30) and hyperbilirubinemia (20 of 60 vs. 5 of 30) was noted among them. Incidence of heavy babies (>3.5 kg) born was also higher in treated group (11 of 60 vs. 3 of 30). The group with abnormal GTT but not treated since they had normal PPS were found to have comparable pregnancy outcome as in normal pregnant controls. Conclusion: All gravidae with abnormal GTT do not require treatment. Abnormal PPS should determine the need for treatment.

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