Quantification of domperidoe, paracetamol, esomeprazole and lansoprazole in pharmaceutical dosage forms by reversed phase high performance liquid chromatography

Vasantharaju, SG and Namita, P and Hussen, Syed Sajjad (2012) Quantification of domperidoe, paracetamol, esomeprazole and lansoprazole in pharmaceutical dosage forms by reversed phase high performance liquid chromatography. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (supl-3). pp. 303-306. ISSN 0975-1491

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Abstract

A simple, sensitive, and accurate high performance liquid chromatographic method developed and validated for the simultaneous estimation of domperidone, paracetamol, esomeprazole, and lansoprazole in pharmaceutical dosage forms .The assay involved the use of photo diode array detection at 285 nm for domperidone, 246 nm for paracetamol, 300 nm for esomeprazole, and 283 nm for lansoprazole. The compounds were well separated on a Supelco C18 (250x4.6mm,5μ) reversed-phase column and mobile phase consisting of 0.01 M, pH 7.00, dipotassium hydrogen phosphate buffer - acetonitrile (65:35 v/v) at a flow rate of 1.0 mL min-1. The linearity range was 0.5 - 50 μg mL-1 for all the four analytes domperidone, paracetamol, esomeprazole and lansoprazole. Limits of detection (LOD) obtained were 0.1 μg mL-1

Item Type: Article
Uncontrolled Keywords: Reverse phase liquid chromatography, Domperidone, Paracetamol, Esomeprazole, Lansoprazole.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Manipal
Date Deposited: 11 Jun 2012 05:42
Last Modified: 11 Jun 2012 05:42
URI: http://eprints.manipal.edu/id/eprint/76636

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