Pro-healing effects of morin,a natural antioxidant,on normal and dexamethasone-imparied wounds

Shenoy, Rekha Raghuveer and Theerthahalli, Arun Sudheendra and Nayak, Pawan Ganesh and Paul, Piya and Kutty, Gopalan N and Rao, Mallikarjuna C (2011) Pro-healing effects of morin,a natural antioxidant,on normal and dexamethasone-imparied wounds. J Basin Clin Physiol Pharmacol, 22 (4). pp. 131-135.

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Abstract

Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally inflicted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 % in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 14 Jun 2012 11:33
Last Modified: 07 Nov 2016 08:54
URI: http://eprints.manipal.edu/id/eprint/76667

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