Pattern of Angiotensin-Converting Enzyme Inhibitors Induced Adverse Drug Reactions in South Indian Teaching Hospital

Mateti, Uday Venkat and Nekkanti, Haritha and Rajesh, V and Thiyagu, Rajakannan and Surulivelrajan, Mallayasamy and Padmakumar, R (2012) Pattern of Angiotensin-Converting Enzyme Inhibitors Induced Adverse Drug Reactions in South Indian Teaching Hospital. North American Journal of Medical Sciences, 4 (4). pp. 185-189. ISSN 1947-2714

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Abstract

Background: Adverse drug reactions (ADRs) occur frequently with cardiovascular drugs leading to change in therapy, increasing morbidity, and mortality. Aim: The study was conducted to evaluate the incidence of ADRs due to angiotensin-converting enzyme Inhibitors in cardiology department. Materials and Methods: A cross-sectional observational study was carried out for a period of 6 months. The data were assessed for the pattern of the ADRs with respect to patient demographics, nature of the reaction, outcome of the reactions, causality, severity, and preventability. Results: Among 692 patients, 51 (7.36%) had developed 60 ADRs, and majority of cases (56.66%) were in the age group of >61 years and most of them were developed in female (80%). The common ADRs observed were cough, hypotension, hyperkalemia, and acute renal failure. In 21.66% cases the dose of the suspected drug was altered and in 78.33% cases the drug was withdrawn. Considering the outcome, 93.33% of cases recovered from ADRs, whereas in 6.66% cases were continuing. Causality assessment showed that majority of ADRs was probable and were found to be moderately severe. Conclusion: Our study concludes geriatrics and female patients have higher incidence of ADRs. So early identification and management of ADRs are essential for this population.

Item Type: Article
Uncontrolled Keywords: Adverse drug reactions, Angiotensin-converting enzymes, Cardiovascular drugs
Subjects: Medicine > KMC Manipal > Cardiology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 16 Jun 2012 04:17
Last Modified: 14 Dec 2015 15:14
URI: http://eprints.manipal.edu/id/eprint/76673

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