Koteshwara, KB and Naha, Anup and Choubey, Bishu (2012) Novel Economical Technique for the Formulation of Fast Dissolving Tablet. Research Journal of Pharmacy and Technology, 5 (4). pp. 483-489.

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Abstract

The objective of current study was to develop a novel and economical method for the formulation of fast dissolving tablet and to investigate the influence of the different superdisintegrants and their concentrations on the characteristics of fast dissolving tablets (FDTs) of Diclofenac sodium. Moulding technique was use because tablets produced by the moulding technique are easier to scale up for industrial manufacture and the technique do not require costly equipment’s. In addition to this the technique can be used for moisture sensitive drugs. By moulding technique FDTs can be directly formulated into final blister pack reducing formulation steps. Drug-excipient compatibility studies were carried out. Micromeritic properties of the formulation blends and Physiochemical characteristics of tablets were evaluated. Stability study was carried out at 40°C and 75% RH in glass vials for 12 weeks. The in vitro dissolution studies of formulations containing different percentage of superdisintegrants were found to be satisfactory. It was observed that all the superdisintegrants were able to disintegrate the tablet within a minute. Stability of the formulations was found to be inversely proportional to superdisintegrant concentration.

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