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Therapeutic Dimensions of ACE Inhibitors- A Review of literature and Clinical Trials

Prabhu , M and Palaian , S and Malhotra , A and Ravishankar , P and Bista , D and Almeida , R and Mishra, P (2005) Therapeutic Dimensions of ACE Inhibitors- A Review of literature and Clinical Trials. Kathmandu University Medical Journal, 3 (3). pp. 296-304.

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Abstract

In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. This gave rise to the development of ACE inhibitors. Surprisingly, the ACE inhibitors proved to be effective not only in patients with high renin hypertension, but also in many patients with normal levels of plasma renin activity. At present ACE inhibitors have a significant position in a wide range of chronic illnesses such as atherosclerosis, hypertension, myocardial infarction, diabetic complications, stroke etc. They are combined safely with drugs like angiotensin receptor blockers, calcium channel blockers and thiazides with varying degree of benefits. Though they are safe drugs, patients need monitoring for renal insufficiency, hypotension, hyperkalemia etc. The safety of these drugs in paediatrics patients is not established. It is better to avoid these drugs during pregnancy.

Item Type: Article
Uncontrolled Keywords: ACE inhibitors, Atherosclerosis, Diabetic complications, Hypertension, Myocardial infarction
Subjects: Medicine > KMC Manipal > Medicine
Depositing User: KMC Manipal
Date Deposited: 16 Jul 2011 09:26
Last Modified: 16 Jul 2011 09:26
URI: http://eprints.manipal.edu/id/eprint/768

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