Photo Stimulatory and Photo Inhibitory Effect of Low Level Laser Therapy in Diabetic Wound Healing Dynamics- Preclinical Study

Mariya Arun, G and Dixit, Snehil and Udupa, P and Rao, Laxmi (2012) Photo Stimulatory and Photo Inhibitory Effect of Low Level Laser Therapy in Diabetic Wound Healing Dynamics- Preclinical Study. International Journal of Health Sciences, 2 (2). pp. 8-14. ISSN 2249-9571

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Abstract

The significances of laser photo stimulation are now accepted generally but the laser light facilitates wound healing and tissue repair remains poorly understood. So we have examined the hypothesis that the laser photo stimulation can enhances the collagen production and histological changes in diabetic wounds using excision wound model in Wister rat. Method: The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N=12) wound was treated with laser with wave length of 660 nm at a dose of 7 j/cm2 and 15j/cm2 for five days a week until the wounds healed completely (wound closed on average 12th day in 7J/cm2 and 19th day in 15 j/cm2). The control group was sham irradiated (Wound closed on average of 28th day). Result: Significant increase in the hydroxyproline content and histopathological changes was observed in study group of 7 J/cm2 as compared to 15 j/cm2. The healing actions seem to be due to increased collagen deposition as well as better alignment and maturation. In conclusion the biochemical and histopathological findings confirms that laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.

Item Type: Article
Uncontrolled Keywords: Laser photo stimulation; Wound healing, Hydroxyproline, histopathology, excision wound
Subjects: Allied Health > MCOAHS Manipal > Physiotherapy
Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 11 Jul 2012 04:40
Last Modified: 11 Jul 2012 04:40
URI: http://eprints.manipal.edu/id/eprint/76807

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