Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in wistar rats

Maiya, Arun G and Kumar, Pramod and Nayak, Shivananda B (2009) Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in wistar rats. Indian Journal of Dermatology, 54 (4). pp. 323-329.

[img] PDF
IndianJDermatol544323-1703233_044352.pdf - Published Version
Restricted to Registered users only

Download (271kB) | Request a copy

Abstract

Background: Generally, the significances of laser photo stimulation are now accepted, but the laser light facilitates wound healing and tissue repair remains poorly understood. Aims: We have examined the hypothesis that the laser photo stimulation can enhance the collagen production in diabetic wounds using the excision wound model in the Wistar rat model. Methods: The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N = 24) wound was treated with 632.8 nm He-Ne laser at a dose of 3-9J/cm 2 for 5 days a week until the wounds healed completely. The control group was sham irradiated. Result: A significant increase in the hydroxyproline content and reduction in the wound size were observed in the study group. The pro-healing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: The biochemical analysis and clinical observation suggested that 3-6 J/cm 2 laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.

Item Type: Article
Uncontrolled Keywords: Clinical observation, hydroxyproline, laser photo stimulation, photo inhibition, wound healing
Subjects: Allied Health > MCOAHS Manipal > Physiotherapy
Depositing User: KMC Manipal
Date Deposited: 12 Jul 2012 04:35
Last Modified: 12 Jul 2012 04:35
URI: http://eprints.manipal.edu/id/eprint/76820

Actions (login required)

View Item View Item