Effect of Low Intensity Helium-Neon (He-Ne) Laser Irradiation on Diabetic Wound Healing Dynamics

Maiya, Arun G and Kumar, Pramod and Rao, Laxmi (2005) Effect of Low Intensity Helium-Neon (He-Ne) Laser Irradiation on Diabetic Wound Healing Dynamics. Photomedicine and Laser Surgery, 23 (2). pp. 187-190.

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Objective: The aim of this study was to determine the effect of low-energy He-Ne laser treatment on wound healing dynamics (histological and biochemical) in diabetic rats. Background data: Low-energy laser photostimulation at certain wavelengths can enhance tissue repair by releasing growth factors from fibroblasts and can facilitate the healing process of diabetic wounds. Materials and methods: A circular 4 cm2 excisional wound was created on the dorsum of the experimentally (Alloxan)-induced diabetic rats. In the study group (N = 24) the wound was treated with He-Ne laser (632.8 nm wavelength) at a dose of 4.8 J/cm2 for 5 days a week until the wound healed completely. The control group (N = 24) was sham-irradiated. The results were statistically analyzed by an independent t test for biochemical analysis and the nonparametric Mann-Whitney U test for histopathological parameters. Results: The analysis of the biochemical parameters and histopathological parameters of the wounds showed that the laser-treated group healed faster and better as compared to the control group (p < 0.0001). The laser-treated group healed on average by the 18th day whereas, the control group healed on average by the 59th day. Conclusion: Laser photostimulation promotes the tissue repair process of diabetic wounds.

Item Type: Article
Subjects: Allied Health > MCOAHS Manipal > Physiotherapy
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Plastic Surgery
Depositing User: KMC Manipal
Date Deposited: 12 Jul 2012 04:52
Last Modified: 12 Jul 2012 04:52
URI: http://eprints.manipal.edu/id/eprint/76821

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