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Fixed drug eruption due to co-trimoxazole: a case report.

Dwari, BC and Bajracharya, S and Gupta, S and Mishra, P and Palaian, S and Alam, K and Prabhu, S and Prabhu, M (2006) Fixed drug eruption due to co-trimoxazole: a case report. Journal of Institute of Medicine, 28 (2). pp. 67-70.

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Abstract

Background: Cotrimoxazole is a synergistic fixed dose combination of sulfamethoxazole and trimethoprim used in treatment of several infections including urinary, respiratory, gastrointestinal tract infections. Because of itswide spectrumand lowcost it is one of themost preferred antimicrobial in Nepal. Fixed drug eruptions (FDEs) are drug rashes which tend to occur at the same site in the particular patient each timewhen an offending drug is administered. Co-trimoxazole is a drug commonly implicated for causing FDEs. Case report:We report a case of FDE due to co-trimoxazole occurred in a patient for whom it was prescribed by a local practitioner without taking adequate medication history. We also carried out the causality, severity, preventability and predictability as well as the economic impact of the associated adverse drug reaction (ADR). The report suggests that before prescribing any drug, clinicians should take appropriate medication history and upon occurrence of any ADR the patient should be counseled and instructed to communicate with the clinicians wherever they attend for the next time.

Item Type: Article
Uncontrolled Keywords: Causality assessment, Co-trimoxazole, Fixed drug eruption, Naranjo algorithm.
Subjects: Medicine > KMC Manipal > Dermatology
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 16 Jul 2011 09:21
Last Modified: 16 Jul 2011 09:21
URI: http://eprints.manipal.edu/id/eprint/769

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