A novel series of homoallylic amines as potential antimicrobials

Rai, Sesappa U and Isloor, Arun M and Shetty, Prakash and Isloor, Nishitha and Padaki, Mahesh and Fun, Hoong-Kun (2012) A novel series of homoallylic amines as potential antimicrobials. Medicinal Chemistry Research , 21 (7). pp. 1090-1097. ISSN 1554-8120

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An efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25�C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity.

Item Type: Article
Additional Information: © Springer
Uncontrolled Keywords: Homoallylic amines � Allyltributyl stannate � CF3COOH � Antibacterial activity
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 14 Aug 2012 09:32
Last Modified: 14 Aug 2012 09:32
URI: http://eprints.manipal.edu/id/eprint/77033

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