Effects of Angiotensin Converting Enzyme Inhibitors on Hemostatic Profile in Rats

Nayak, Gurudutt and Herur, Gopala Krishna N and *, Rathnakar U P and Shenoy, Ashok and Ullal, Sheetal and Pemmineti, Sudhakar and Shetty, Nivedita and Shastry, Rajeshwari (2012) Effects of Angiotensin Converting Enzyme Inhibitors on Hemostatic Profile in Rats. Journal of Pharmacy Research, 5 (6). pp. 3290-3292.

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Abstract

Recent studies have indicated that angiotensin II [ANG II] might influence platelet activation & coagulation process suggesting prothrombotic activity. Experimental studies have indicated that ANG II is involved in arterial thrombus formation which is considered as a risk factor for adverse cardiovascular events such as MI & stroke. Very limited data available about the effects of ACEIs on coagulation profile such as bleeding, clotting & prothrombin time, either alone or in combination with aspirin prompted us to perform this study in experimental animals to evaluate the effects of ACEIs alone and in combination with Aspirin on hemostatic profile in rats. Materials and Methods: Various doses of lisinopril, ramipril and their combinations with aspirin were tested for their effect on hemostatic profile in albino Wistar rats. Discussion and conclusion: Pronounced prolongation in bleeding time & prothrombin time with the tissue ACEI (Ramipril) and its combination with aspirin compared with the plasma ACEI (Lisinopril), is demonstrated, in normal rats.

Item Type: Article
Uncontrolled Keywords: ACEIs, clotting time, bleeding time, INR
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 18 Aug 2012 05:19
Last Modified: 18 Aug 2012 05:19
URI: http://eprints.manipal.edu/id/eprint/77052

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