Sujitha, M and Rathnanand, Mahalaxmi (2012) Preparation and evaluation of orally disintegrating tablets of Telmisartan with pH independent release. International Journal of PharmTech Research, 4 (3). pp. 1154-1158. ISSN 0974-4304

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Abstract

Abstract: The objective of the study is to optimize, formulate and evaluate orally disintegrating tablet (ODT) of Telmisartan which disintegrates with in few seconds there by having better patient compliance, and achieve drug release independent of pH. Telmisartan(Angiotensin Receptor Blocker, ARB) is an anti hypertensive agent indicated in patients who cannot tolerate Angiotensin Converting Enzyme (ACE) inhibitors and for patients with LV(left ventricular) dysfunction. The ODTs were prepared using Betacyclodextrin and evaluated for weight variation, thickness, hardness, disintegration and in vitro dissolution studies. Stability studies of optimized formulation was carried out as per ICH guidelines at 40 ± 20C / 75 ±5% RH for three months and was found stable.

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