Nagamma, T (2007) Roll of hyperglycemic induced oxidative stress in diabetes mellitus. Journal of College of Medical Sciences-Nepal, 4 (1). pp. 38-50.

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Abstract

Diabetes mellitus is a multifactorial disease showing a rising trend all over the world. In recent years the importance of free radical induced oxidative stress has been attributed as one of the co-player in the etiopathogenesis of diabetes mellitus.Chronic elevation of blood glucose, which ultimately metabolised by autoxidation, advanced glycation end products, polyol pathway, hexosamine pathway,pritein kinase C pathway , and activates the stress-sensitive pathways, which have common role in the formation of reactive oxygen species. The excess of reactive oxygen species causes oxidative stress, which in turn causes defective insulin gene expression, insulin secretion, apoptosis of a-cells.

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