Metronomic Therapy for Malignant Peripheral Nerve Sheath Tumor in Neurofibromatosis Type 1

Chaudhary, Narendra and Borker, Anupama (2012) Metronomic Therapy for Malignant Peripheral Nerve Sheath Tumor in Neurofibromatosis Type 1. Pediatric Blood & Cancer. pp. 1-3.

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Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive tumor especially in the patients with neurofibromatosis type 1 (NF1). Without a complete surgical excision, prognosis is guarded. We describe a 10-year-old male with NF1 with MPNST, who had a local relapse within 5 weeks of surgical excision. Chemoradiotherapy did not result in tumor regression. Initiation of palliative oral metronomic therapy resulted in complete remission after six cycles. The patient continues to be in remission, 20 months after completion of nine cycles of metronomic therapy. Metronomic therapy may be effective in MPNST where conventional chemotherapy and radiotherapy fails. Pediatr Blood Cancer.

Item Type: Article
Uncontrolled Keywords: malignant peripheral nerve sheath tumor; metronomic chemotherapy; neurofibromatosis type-1
Subjects: Medicine > KMC Manipal > Paediatrics
Depositing User: KMC Manipal
Date Deposited: 04 Sep 2012 06:22
Last Modified: 04 Sep 2012 06:22
URI: http://eprints.manipal.edu/id/eprint/77112

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