Kini, Rajesh U and Kamath, Deepak and Rathnanand, Mahalaxmi (2012) Formulation and Evaluation of Carbamazepine extended release tablet by controlled erosion technology. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4). pp. 345-351. ISSN 0975-1491

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Abstract

The objective of the present study was to design and develop the carbamazepine extended release tablet fabricated by controlled erosion technology. The core tablets were prepared by wet granulation technique using hydroxypropyl methyl cellulose E5 as hydrophilic matrix. The prepared core matrix tablets were characterized for weight variation, hardness, friability, thickness and drug content. The erosion controlled coating was applied to the core tablets using cellulose acetate as the polymer to retard drug release. In vitro dissolution studies for both the core and the coated tablets were carried out in distilled water using USP Type II dissolution apparatus. The optimized formulation showed a release of 85.3% release in 12 hours complying with USP limits. The mathematical models were applied to study the release kinetics of the optimized tablets. The stability study of the optimized formulation was done as per ICH guidelines (40±2 ºC/75±5%RH) for 3 months and all the prepared formulations were found to be stable.

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