Role of statins in animal models of anxiety in Normo-cholesterolemic rats

Pemminati, Sudhakar and *, M.B. Nandini Colaco and *, D Patchava and *, G.Shivaprakash and *, D.Sheetal Ullal and *, H.N.Gopalakrishna and *, U.P. Rathnakara and Shenoy, Ashok K (2012) Role of statins in animal models of anxiety in Normo-cholesterolemic rats. Journal of Pharmacy Research, 5 (7). pp. 3764-3766. ISSN 0974-6943

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Abstract

There is growing evidence that statins play a role in many of the central nervous disorders. Though there are studies reporting statins modulate functions of neurotransmitters and receptors involved in mood disorders, little research has been made to evaluate its potential in anxiety disorder where alteration of neurotransmitters is an established factObjective: To evaluate the anxiolytic-like activity of atorvastatin and simvastatin in normo-cholesterolemic rats. Material andMethods: Anxiolytic activity was evaluated by employing the two pharmacologically validated models, elevated plus maze and light and dark box. The rats were divided into eight groups, each group containing six animals. The effects of the test drugs atorvastatin (0.45, 0.9, 1.8 mg/kg/day),simvastatin (0.22, 0.45 & 0.9 mg/kg/day), the standard anxiolytic, alprazolam (0.045 mg/kg/day) and control group 1% gum acacia (10ml/kg) were assessed after adminitering the drug for 14 days. Results: In elevated plus maze atorvastatin at dose 0.9mg/kg and simvastatin at doses 0.45mg/kg and 0.9mg/kgincreased number of open arm and total arm entries, percentage ratio of open/total arm entries, time spent and number of rears in open arm and decreased time spent in closed arm. In light and dark box, atorvastatin at dose 0.9mg/kg, simvastatin at doses 0.45mg/kg and 0.9mg/kg increased number of entries, time spent, number of rears in bright chamber and decreased duration of immobility. Conclusion: The results suggest that the behaviouraldisinhibitory effects of atorvastatin and simvastatin are similar to the behavioural effects of alprazolam.

Item Type: Article
Uncontrolled Keywords: Anxiolytic, Elevated plus maze, normo-cholesterolemic, Alprazolam
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 25 Sep 2012 09:31
Last Modified: 25 Sep 2012 09:31
URI: http://eprints.manipal.edu/id/eprint/77269

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