Study of Oxidative stress, bone mineral status and fluoride levels in postmenopausal women in endemic fluorotic area of andhra pradesh, India

Rao, Pragna (2012) Study of Oxidative stress, bone mineral status and fluoride levels in postmenopausal women in endemic fluorotic area of andhra pradesh, India. International Journal of Pharmacy and Biological Sciences, 2 (2). pp. 77-83. ISSN 2230-7605

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Abstract

Osteoporosis is a major health problem of old age. This silently progressing metabolic bone disease is widely prevalent in India, the prevalence of osteoporosis increases with age especially involving long bones. It has been observed that females suffer from osteoporosis, after the menopause, accelerated process of osteoporosis occur and it is observed in India that about 50% suffer from osteoporosis and estimated number is 30 million. Fluorosis is a serious public health problem in many parts of the world where drinking water contains more than 1 ppm of fluoride. Higher intake of fluoride will result in dental and skeletal fluorosis and affect collagen synthesis and bone mineralization. Approximately 99% of the body burden of fluoride is associated with calcified tissues. The fluoride concentration in bone is not uniform. Fluoride concentration in bone is not uniform and higher fluoride levels in the body are associated with calcified tissues.The study was conducted on 100 subjects with their consent which consisted of control group of 50 non-pregnant women in their reproductive age group. Study group consisted of 50 women who had attained menopause either naturally or surgically, all residing in the endemic fluorotic area of Nalgonda district, Andhra Pradesh, India. 5 ml of venous blood was collected from both the groups. Serum fluoride levels (0.68  0.39; p<0.005) was statically significant when compared to the controls (0.45  0.28). The biochemical parameters of bone mineral status, serum calcium (9.19  0.620) p= 0.488 and serum phosphorus (4.27  0.71; p = 0.799) was statistically insignificant whereas total alkaline phosphatase (132  37.60; p< 0.001) and bone specific alkaline phosphates (97.41  38.74; p< 0.001) were statistically significant indicating that there is more osteoblastic activity in patients of osteoporosis. Malondialdehyde was measured as an indicator of oxidative stress which was statistically significant (287.86  49.79; p<0.001). Bone turnover markers, serum total ALP and BSALP have a role in assessment of fluorosis in postmenopausal women and serum malondialdehyde, a lipid peroxidation product, is used as an indicator of oxidative stress which is induced by fluorosis.

Item Type: Article
Uncontrolled Keywords: Fluorosis, post menopausal women, malondialdehyde, oxidative stress, osteoporosis.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 05 Oct 2012 06:23
Last Modified: 05 Oct 2012 06:23
URI: http://eprints.manipal.edu/id/eprint/77342

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