Evaluation of the Antioxidant Activity of Novel Synthetic Chalcones and Flavonols

Venkatachalam, H and Nayak, Yogendra and Jayashree, BS (2012) Evaluation of the Antioxidant Activity of Novel Synthetic Chalcones and Flavonols. International Journal of Chemical Engineering and Applications, 3 (3). pp. 216-219.

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In the present study, newer chalcones and flavonols were synthesized by Algar-Flynn-Oyamada method, purified and characterized by spectral methods. The pure test compounds were evaluated for in vitro antioxidant activity using four models namely 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH•), 2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•), Nitric oxide (NO) and Lipid Peroxidation scavenging methods. This study indicate that, amongst the ten evaluated chalcones and flavones, five test compounds showed activity with IC50 value lesser than that of the standard ascorbic acid at 91.21 μM for 2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging.

Item Type: Article
Uncontrolled Keywords: Antioxidant, Chalcones, Flavonols.
Subjects: Health Sciences > KMCIC
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: MIT Library
Date Deposited: 06 Oct 2012 09:05
Last Modified: 05 Oct 2013 07:22
URI: http://eprints.manipal.edu/id/eprint/77350

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